Personalized dosimetry for 90Y


Thanks to the latest advances in medical imaging and oncology tracers we are arriving to an era in which personalized medicine is finally a reality.


90Y selective internal radiotherapy (SIRT) is a good example of the possibilities that the future affords.

 

The initial challenges of acquiring 90Y images in diagnostic quality have been meanwhile sorted out. The time is ripe to concentrate efforts on the application related dosimetry questions, i.e. in the quantification and transpolation evaluation of dose distribution and uptakes. Imalytics, with its flexible approach, provides state-of-the-art tools for the dosimetry analysis of 90Y, including:

 

• Voxel-wise residence time and energy-dose

• calculation of voxel-wise energy-dose distribution using different approuches:
    • Convolution using Dose-Volume-Kernel (DVK)

     Local Deposite Method (LDM)

• Physically correct kernels for 90Y

• Dose statistics per region and dose-volume-histograms

 

The dosimetry analysis in Imalytics takes place in just four steps, as you can see on the right side.

 
Goedicke A, Berker Y, Verburg FA, Behrendt FF, Winz O, Mottaghy FM. Medical Imaging, Volume 32, Issue 3, March 2013, Pages 485-492
 
Berker Y, Goedicke A, Kemerink GJ, Aach T, Schweizer B. Eur. J. Nucl. Med. Mol. Imaging, Volume 38, Issue 12, December 2011, Pages 2173-2185

Wierts R, de Pont CD, Brans B, Mottaghy FM, Kemerink GJ. Methods, Volume 55, Issue 3, November 2011, Pages 196-202

Schweizer B, Schaefer A, Donsch P, Kremp S, Gouverneur E, Farmakis G, Grgic A, Bal M, Kirsch CM, Hellwig D. Eur. J. Nucl. Med. Mol. Imaging, Volume 36, Issue 2 Supplement, September 2009, Page 428

 

Caution: Imalytics and its modules are for research purposes only. Not for patient diagnosis or patient treatment planning.