In the treatment of coronary artery disease, clinicians have been using FFR in addition to angiographic images to assess the physiology of a suspected blockage in coronary arteries in order to identify the appropriate therapy for each patient. iFR is a next-generation physiologic measurement that uses the same pressure guide wires and equipment as FFR, but avoids the administration of hyperemic agents, which are required with FFR, to the patients.
“The DEFINE FLAIR study has provided further clinical validation of iFR and how it is improving the lives of patients and physicians,” said Christopher Barys, Business Leader of Philips Image Guided Therapy Devices. “An iFR-guided strategy has now been shown to improve patient outcomes and reduce costs for the treatment of coronary artery disease in comparison to an FFR-guided strategy. This is a significant step in our journey to help clinicians decide, guide, treat and confirm the right therapies for their patients, while reducing costs.”
DEFINE FLAIR is a randomized, controlled, single-blinded comparison of clinical outcomes and cost efficiencies of iFR and FFR-guided interventions of 2,492 patients in 49 centers across Europe, Asia, North America, and Africa. The study conducted its comparison of iFR versus FFR using pressure guide wires and equipment from Philips. Since the introduction of the hyperemia-free iFR modality in 2013, iFR has been studied in nearly 15,000 patients and is used in more than 4,100 catheterization labs across the world.
See Philips’ calendar of events for ACC, as well as general information about the company’s presence at the show, online here. Visit the Philips booth (#2811) to experience its innovative cardiology portfolio that delivers integrated solutions to the full health continuum. Follow the #ACC18 conversation on @PhilipsLiveFrom throughout the event.
 Coronary Artery Disease, NIH, 2015
 Davies JE, et al., DEFINE-FLAIR: A Multi- Centre, Prospective, International, Randomized, Blinded Comparison of Clinical Outcomes and Cost Efficiencies of iFR and FFR Decision-Making for Physiological Guided Coronary Revascularization. New England Journal of Medicine, epub March 18, 2017