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Personalized dosimety for 90Y

Personalized dosimetry for 90Y


Thanks to the latest advances in medical imaging and oncology tracers we are arriving to an era in which personalized medicine is finally a reality.


90Y selective internal radiotherapy (SIRT) is a good example of the possibilities that the future affords.

 

The initial challenges of acquiring 90Y images in diagnostic quality have been meanwhile sorted out. The time is ripe to concentrate efforts on the application related dosimetry questions, i.e. in the quantification and transpolation evaluation of dose distribution and uptakes. Imalytics, with its flexible approach, provides state-of-the-art tools for the dosimetry analysis of 90Y, including:

 

• Voxel-wise residence time and energy-dose

• calculation of voxel-wise energy-dose distribution using different approuches:
    • Convolution using Dose-Volume-Kernel (DVK)

    • Local Deposite Method (LDM)

• Physically correct kernels for 90Y

• Dose statistics per region and dose-volume-histograms

 

The dosimetry analysis in Imalytics takes place in just four steps, as you can see on the right side.

  • 1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags

  • 2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures

  • 3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually

  • 4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

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Images

  • 1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags

    1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags

  • 2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures

    2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures

  • 3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually

    3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually

  • 4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

    4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

  • 1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags

    1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags

  • 2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures

    2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures

  • 3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually

    3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually

  • 4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

    4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

1. Study setup: The images and the acquisition time can be reviewed while setting the calibration factors. In order to make a proper dosimetry analysis, you are required to define the activity provided by the isotope. Other important data for the analysis is taken from the respective DICOM tags
2. Registration: Functional images get aligned with the anatomical ones to easily and reliable identify and select structures
3. Segmentation: Target organs or lesions required for the analysis as volumes of interest are defined; this can be done automatically or manually
4. Dose Calculation and Evaluation: The software provides you the dose map and volume histograms as well as time activity curves and valuable statistics. A html based report can be generated, including the images as you have seen them in the viewers as well as the respective histograms, curves and statistics

Publications

 
Goedicke A, Berker Y, Verburg FA, Behrendt FF, Winz O, Mottaghy FM. Medical Imaging, Volume 32, Issue 3, March 2013, Pages 485-492
 
Berker Y, Goedicke A, Kemerink GJ, Aach T, Schweizer B. Eur. J. Nucl. Med. Mol. Imaging, Volume 38, Issue 12, December 2011, Pages 2173-2185

Wierts R, de Pont CD, Brans B, Mottaghy FM, Kemerink GJ. Methods, Volume 55, Issue 3, November 2011, Pages 196-202

Schweizer B, Schaefer A, Donsch P, Kremp S, Gouverneur E, Farmakis G, Grgic A, Bal M, Kirsch CM, Hellwig D. Eur. J. Nucl. Med. Mol. Imaging, Volume 36, Issue 2 Supplement, September 2009, Page 428

 

Caution: Imalytics and its modules are for research purposes only. Not for patient diagnosis or patient treatment planning.