Philips supports CNIC to shape the future of cardiac care
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This week, the first international consensus document to provide guidelines for MRI studies during clinical trials after a patient has suffered a myocardial infarction (also known as a heart attack) has been published in the Journal of the American College of Cardiology (JACC).
MRI is increasingly used to assess the heart after a myocardial infarction, gauging a patient’s risk for future events, understanding the changes taking place in cardiac tissue and evaluating treatment options. By supporting a more consistent application of cardiac MRI during clinical and experimental trials and making their results more easily comparable, the document’s authors believe the recommendations will have a significant positive impact.
The document concludes that the main outcome parameter in studies assessing new treatments should be absolute infarct size, i.e. the percentage of the left ventricle (heart chamber) that is irreversibly damaged. The guidelines also recommend that the MRI study should be carried out between three and seven days after the infarction. They also address the need within the cardiovascular community for guidance on the best protocols, the best techniques, and the most appropriate situations for conducting MRI studies after a myocardial infarction.
The lead scientists for the consensus document are Dr Borja Ibañez, Clinical Research Director at the CNIC, consultant cardiologist at Fundación Jiménez Díaz hospital, and a member of the CIBERCV cardiovascular research network; and Dr Valentín Fuster, Director of the Cardiovascular Institute and Medical Director at Mount Sinai Hospital in New York.
“Magnetic resonance imaging is one of the best methods for studying the heart after an infarction,” said Dr Fuster. “It allows the study of heart anatomy, function, and tissue composition in a very precise way without exposing the patient to radiation. Magnetic resonance imaging is the ideal method for assessing the effect of new treatments. However, until now the community has lacked consistent recommendations on the specific procedures to follow after an acute myocardial infarction in order to assess the effect of these treatments.”
Magnetic resonance imaging is the ideal method for assessing the effect of new treatments.
Dr Valentín Fuster
Director of the Cardiovascular Institute and Medical Director at Mount Sinai Hospital in New York
“Consensus documents of this type provide guidelines to ensure consistency in the use of important tools such as this one,” said Dr Ibañez. “Currently, many clinical trials use magnetic resonance imaging to assess a principal outcome, but it is very difficult to compare these studies because they use widely different protocols. Myocardial infarction affects millions of people in the world every year, and this is therefore a highly active field of research. Because of this, the implications of the new consensus document are enormous.”
The document’s contents were defined during an international meeting of 16 experts in the field, hosted by CNIC with the support of Philips.
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